The Huichol or Wixarika culture is one of the most important in Mexico. They are carriers of traditions transmitted from generation to generation. Their customs have been present since ancient times. They have values that are fundamental for the union of their community. From the theoretical approach of Resources and Capabilities, this empirical study aims to analyze how the cultural aspects influence the economic performance of small wixarika artisan businesses. The methodology used was multiple regression analysis. The construct “cultural aspects” was elaborated based on the literature review. The results show that the customs variable, measured through “making of handcrafted pieces as his parents taught him,” influences the income from the business. The variables tradition inherited from generation to generation and the values that parents instill in the business do not influence their economic performance. It concludes with the need to dignify and value the work of the artisans.