To identify the level of adherence to pharmacological and non-pharmacological treatments according to age, sex and time of evolution in patients with diabetes mellitu.Cross-sectional observational analytical descriptive study, population 739 patients, with a sample of 272, which were randomly selected. Bonilla questionnaire validated with a Crombach alpha of 0.86 was applied. Tests were made for the variables age, sex and time of evolution to compare it with the variable level of adherence, with the corresponding descriptive statistics. Additionally, bivariate analysis to determine the association of the level of adherence with the variables age, sex and time of evolution.63% were female, 37% were male. The average age was 54.93 +/- 12.44 years and the evolution time was 7.6 +/- 3.7 years. Regarding the level of adherence, the 272 participants had an average score of 70.53 +/- 11.38, which indicates that they are at risk of non-adherence to treatments.Non-adherent behavior in patients with diabetes continues to be a concern, which is why governments continue to invest in educational programs for patients and their families to control diabetes and prevent its complications.