Examples of symptoms that likely reflect endorphin excess or deficiencyEndorphin excess (medical) Endorphin deficiency (medical)Obesity, overeating without feeling hungry 1,14,15 Inability to gain weight/poor appetite 1,16 Tendency to low blood pressure and heart rate 13,16 Tendency to high blood pressure and heart rate 16,21 High acute pain threshold 4,5,9,16 Low acute pain threshold [16][17][18][19][20] Chronic pain 4,5,11 Chronic pain 19,20 Pruritus 8 Bladder dysregulation 16,22 Cholestasis 8 Hyperinsulinemia/hypoglycemia 16 Opioid overuse-opioids induce euphoria more than pain and mood improvement 5,11,16 Opioid overuse-opioids help to improve pain and mood 16,20 Opioid-induced hyperalgesia 11,16 Addictive behavior 18,23 Urinary retention 16,22 Endorphin excess (psychiatric) Endorphin deficiency (psychiatric)Low appetite 1,12,[14][15][16] Impulsivity 23,24 Fatigue, oversleeping 2,4,12,16 Moodiness 19,20,24 Low motivation 2,4,7,10 Psychomotor retardation 16,24 Self-mutilation 12 Self-mutilation 24Depression more than anxiety 2,5,6 Anxiety more than depression 23,24 High self-esteem 2-4,7,9,10 Hypoactive sexual desire 24Intensely pleasurable sensations and euphoria 2,4,9,10 Acupuncture and exercise help mood/pain 17 Emotional sensitivity 24Alcohol abuse 23Insomnia 24