Objective: To determine the effectiveness of Tapentadol in cancer patients with neuropathic pain.Material and methods: A descriptive, longitudinal, observational and prospective study was carried out including patients with cancer diagnosis and neuropathic pain treated at the pain clinic between January 1, 2014 and December 31, 2019.Results: 63 patients with a mean age of 59.07 ± 11.06 years were included, of which 76.2% (n = 48) were female.In the EVERA (verbal analog scale) and DN4 (neuropathic pain in 4 questions) scales, a significant difference was observed after treatment and when Tapentadol was initially used, a lower proportion of adverse effects was observed.Conclusions: Tapentadol proved to be an equally effective tool as other treatments, both as an initial or rotation drug, and when used as first line, it had better tolerability.