Encephalitis is a severe neurological syndrome with a rapid progression to encephalopathy caused by brain swelling. One of its causes is antibodies against neuron surface proteins, ionic channels, or receptors so that they can start encephalitis with psychiatric symptoms. Worldwide, auto-immune encephalitis annual incidence is 12.6 per 100000 inhabitants. We present a case report of a 44-years-old female who developed behavioral changes and seizures in a time-lapse of months. She was diagnosed with anti-GABA auto-immune encephalitis, a rare type of this disease. Keywords. Auto-immune disease – Epilepsy – Mental disorders – Neurology – Critical Care