This is a protocol for a Cochrane Review (Intervention). The objectives are as follows: To assess the effects of prophylaxis with RSV monoclonal antibody compared with placebo, no prophylaxis or another type of prophylaxis for reducing the risk of hospitalization due to RSV infection in high‐risk infants and children. To assess the effects of prophylaxis with RSV monoclonal antibody as assessed by the use of resources, compared with placebo, no prophylaxis or another type of prophylaxis. To assess the incremental costs associated with changes in resource use in patients receiving RSV monoclonal antibody prophylactically, compared with placebo, no prophylaxis or another type of prophylaxis.