Objective To establish the therapeutic action of a nicotinic cholinergic agonist agent (CA) composition in the symptoms in a group of human patients infected with SARS-CoV-2 vs. control group. Methods Basic Odds Ratio study (95% confidence interval) in 20 patients for intervention group and 15 patients for the control group. The evaluation in the groups was carried out during 15 days assessing the improvement or worsening of each symptom daily. Results: Cough, (OR = 0.5), Dyspnea (OR = 0.38), Muscle fatigue (OR = 0.69), Ageusia (OR = 0.27), Anosmia (OR = 0.21) General malaise (OR = 0.62), are less than 1 converting the use of the cholinergic agent in a protective and therapeutic factor showing therefore improvement of these symptoms, after its use, compared to the control group. Conclusions: The positive results obtained on the symptoms caused by COVID-19 using cholinergic agonists molecules by delivering a cholinergic agent (CA) composition with special oral and nasal route of administration and specific pharmacological design against COVID-19 in humans infected by SARS-CoV-2 versus the control group, endorse preliminary the nicotinic hypothesis on SARS-CoV-2 and the therapeutic potential of the use of these molecules. Larger multicentrical trials in humans are encouraged.