Measuring life quality (LQ) allows establishing the general subject's perception on the health processes - disease, the treatment started and the perception on health. Objective: To measure LQ in subjects with different cancer types in the city of Bucaramanga, Colombia. Method: A non-experimental descriptive study was carried out in the foundation for cancer relief (Acronym in Spanish AVAC). To measure LQ, the EORTC QLQ-C30 questionnaire was applied. Results: The study population consisted of 40 subjects of which 45% (n = 18) were hospitalized and 55% (n = 22) were in the outpatient program, the average age was 60.98 ± 11.5 years, the predominant gender is female (72.5%), the average time of cancer evolution 4.68 ± 5.17 years, breast cancer was predominant in females and prostate cancer in males, the overall average EORTC QLQ-C30 questionnaire score was 60 ± 9.3 points, the types of cancer that showed the highest scores were lymphoma, colon cancer and thyroid, while the lowest score was multiple myeloma and prostate cancer. Discussion: In relation to the measurement of LQ, the importance of the evaluation is clearly established, since it is a subjective phenomenon. Subjects with high scores must be the object of special care and concern when planning health care activities.