Transnational crimes represent both a challenge and a threat. A challenge for the global community that embraces the acts perpetrated and a threat for the victims who are continually facing a misunderstanding of their situation. Colombia has been involved in dynamics of transnational crimes historically, but the focus was mainly given to illicit drug trafficking. The present paper will make a revision of the current situation of Colombia regarding Human Trafficking because of the vulnerabilities led by female migration and aims to draw the attention into what has been catalogued as the third major thread in terms of transnational organized crimes.