Within the head and neck neoplasms, odontogenic myxoma is considered as a benign neoplasm that can present an aggressive behavior. It is frequently associated with an important recurrence rate that is possibly related to incomplete resection. Among the most common surgical behaviors that can be followed to treat this lesion, we can find curettage or curettage with a peripheral osteotomy to reduce its recurrence rate. The use of a laser has been increasing, presenting good results in different procedures in the oral and maxillofacial region. The aim of this study is to propose an alternative treatment combining the use of the CO2 laser with the conventional curettage technique in order to reduce the risk of recurrence of the odontogenic myxoma and avoid invasive procedures that will affect the quality of life of the patient.