We report a case of Purulent pericarditis and pneumopericardium by Streptococcus angiosus in 35-year-old man detained in prison, history of ischemic cerebrovascular event due to cocaine, with no recent surgical or traumatic history who had subacute clinical course of chest pain and signs of systemic inflammatory response. He was empirically treated with vancomycin and cefepime with subsequent pericardiotomy and drainage. The patient has a poor clinical evolution after the procedure, presents septic shock and dies. This is a rare case, a serious infection, the second reported in world, however in comparison to the first case the clinical course was different.