Event Abstract Back to Event African genetic ancestry influences allergic rhinitis susceptibility in a rural population of the Bolivar department, Colombia. Beatriz Martinez1, Juan Builes2, 3, Catherine Meza1, Luz Hernandez1, 2, Diana Aguirre2, Libardo Mendoza2, Carlos Afanador2, Luis Fang4 and Javier Marrugo1* 1 Institute for Immunological Research, University of Cartagena, Colombia 2 Genes SAS, Laboratory, Colombia 3 Institute of Biology, University of Antioquia, Colombia 4 GITOUC, Colombia Rationale: Allergic rhinitis is the most prevalent allergic diseases. Is considered a multifactorial diseases, because in its pathogenesis are involved environmental and genetic factors. The population of the sub region of Montes de Maria, in the Bolivar department from Colombia is the result of admixture between the European settlers, African slaves and Native Americans. The aimed of this study was to determine if an ancestral component was associated with allergic rhinitis in a sample of this multiethnic population. Methods: An analytical case-control study was performed with 69 individuals diagnosed with allergic rhinitis according ARIA criteria and 75 healthy subjects. In order to know the ancestral composition in this region, we obtained the genetic profile of 46 ancestry informative Indels (AIM-InDels). The ancestral components were calculated using STRUCTURE v2.3.3 with a burnin length of 100,000 followed by 100,000 MCMC, with a K = 3, considering the ''Admixture Model'' and correlated allele frequencies. Logistic regression models were used to estimate the average of ancestry of each group, P values <0.05 were significant. The diagnostic of allergic rhinitis was assessed by using nasal challenge test. Total specific IgE to B. tropicalis and D. pteronyssinus were determined by ImmunoCAP. Results: African ancestry showed a statistically significant difference between cases and controls group (22.2% ± 7.0% vs 20.1 ± 5.6,p = 0.041); additionally this component was also significantly associated with susceptibility of rhinitis (OR: 1.05; 95% CI: 1.01 - 1.1, p = 0.046). All ancestry estimates were tri-hybrid. European ancestry was the most prevalent component but it not showing significant differences between both groups. Conclusions: Our results showed that this population is a tri-ethnic ancestral mixture (European, Native American and African) according to historical data; where the African ancestral component is associated with susceptibility to allergic rhinitis. Conflict of Interest: none Keywords: Alergic rhinitis, ancestry, InDel marker, Blomia tropicalis, Dermatophagoides pteronyssinus Conference: IMMUNOCOLOMBIA2015 - 11th Congress of the Latin American Association of Immunology - 10o. Congreso de la Asociación Colombiana de Alergia, Asma e Inmunología, Medellin, Colombia, 13 Oct - 16 Oct, 2015. Presentation Type: Poster Presentation Topic: Allergy Citation: Martinez B, Builes J, Meza C, Hernandez L, Aguirre D, Mendoza L, Afanador C, Fang L and Marrugo J (2015). African genetic ancestry influences allergic rhinitis susceptibility in a rural population of the Bolivar department, Colombia.. Front. Immunol. Conference Abstract: IMMUNOCOLOMBIA2015 - 11th Congress of the Latin American Association of Immunology - 10o. Congreso de la Asociación Colombiana de Alergia, Asma e Inmunología. doi: 10.3389/conf.fimmu.2015.05.00273 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers' terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 15 May 2015; Published Online: 14 Sep 2015. * Correspondence: Prof. Javier Marrugo, Institute for Immunological Research, University of Cartagena, Cartagena, Bolivar, Colombia, jmarrugoc@unicartagena.edu.co Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Beatriz Martinez Juan Builes Catherine Meza Luz Hernandez Diana Aguirre Libardo Mendoza Carlos Afanador Luis Fang Javier Marrugo Google Beatriz Martinez Juan Builes Catherine Meza Luz Hernandez Diana Aguirre Libardo Mendoza Carlos Afanador Luis Fang Javier Marrugo Google Scholar Beatriz Martinez Juan Builes Catherine Meza Luz Hernandez Diana Aguirre Libardo Mendoza Carlos Afanador Luis Fang Javier Marrugo PubMed Beatriz Martinez Juan Builes Catherine Meza Luz Hernandez Diana Aguirre Libardo Mendoza Carlos Afanador Luis Fang Javier Marrugo Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.