The Cayos region is located in a basin that has been practically unexplored due to the lack of geophysical surveys (principally seismic prospection). This is a preliminary study between the ANH (Agencia Nacional de Hidrocarburo ) and the Universidad Nacional de Colombia with seismic information seeking to show the oil Potential of the Cayos Basin. With this approximation the structural and stratigraphy feature is described, it is based on the seismoestratigraphic and seismic geomorphology interpretation. The Cayos Basin is on the top of the Caribbean Plate with 144.755 Km2 of extension and located at the East of the Nicaragua platform and south of the Jamaican Platform. The mentioned area has a sedimentary package with the presence of uplifted blocks (horst); the sedimentary sequences are associated to the intrusion of the crystalline basement, with some tectonic influence. The geomorphology was initially describe, it is based on satellite images, it is possible to observe structural high geoforms, as well as the Cayos slope, thus geoforms are corroborate through the seismic information, which was used to establish the acoustic basement as well as unconformities and disconformities fount.