The present study presents the results of applying an innovative and practical method to relate the compressive strength measured with the sclerometer and the compression machine, on concrete cylinders with ages of 3 days, 7 days, 14 days, 21 days and 28 days and design strengths of 17.5 MPa, 21 MPa, 24.5 MPa and 28 MPa.Fine aggregate from the Sinú River (Lorica, Córdoba, Colombia) and coarse quarry aggregate (Toluviejo, Sucre, Colombia) were used to manufacture the concrete.The use of the sclerometer is proposed to estimate the resistance of concrete structures that are made of the aforementioned materials, and thus decrease the negative impact generated by the extraction of cores.For this purpose, the calibration curves of the equipment supplied by the supplier and the results obtained through a series of tests carried out were taken as comparative parameters.