This study was conducted to assess the effectiveness of structured education programme on the knowledge of PCOS among female university students. A validated questionnaire was administered to all the 244 participants to assess the baseline knowledge. The post intervention knowledge scores were assessed by administration of questionnaire again following a structured education programme on PCOS. A statistically significant difference was observed between pre and post intervention knowledge scores with p value 0.000. The knowledge of participants was improved through structured education programme that can play a vital role in prevention and early diagnosis of PCOS. This may also help in effective management of disease thereby preventing many long term complications.