Background: The Nocardia is described as an infectious agent of systemic involvement especially in immunocompromised patients. From what we wanted to describe the case of a patient with type-2 diabetes mellitus developed a severe systemic infection with fatal outcome. Methods: We describe the case of a farmer of 62 years from the lower Cauca Colombia, who presented a clinical that begins with 2 months whitish lesions in the mouth, associated with persistent fever and gradual onset of cough, hemoptysis, dyspnea, cyanosis and generalized pustule skin lesions with budding tree display and cavitary lesions in lung and liver abscess only, with no echocardiographic vegetations and negative blood cultures. In skin culture displayed filamentous gram-positive bacteria compatible with Nocardia. Results: The patient has an unfavorable clinical course with eventual development of multiple organ failure and death. Conclusion: Nocardiosis should be taken into account as an etiologic agent in immunocompromised patients from rural areas with systemic manifestations and progressive clinical deterioration. Abstracts for SupplementInternational Journal of Infectious DiseasesVol. 14Preview Full-Text PDF Open Archive