Hirayama disease is a rare self-limiting cervical myelopathy characterized by juvenile muscular atrophy of the distal upper extremities.Hirayama disease was first reported in the eastern world literature, including Asia and India.However, reports from outside of these geographic regions are increasing.Therefore, clinicians and radiologists should be aware of and familiarize themselves with the clinical features and imaging findings of this disease.We report the cases of two young Colombian males: the first individual had an atypical course affecting both upper limbs; the second male had numbness after several cervical traumas.Both individuals had Hirayama disease based on MRI (Magnetic Resonance Imaging) criteria.MRI scan in neutral position revealed atrophy and gliosis in the anterior horn of the lower cervical spine, and MRI scan with neck flexion showed anterior displacement of the posterior dura in both cases.