This paper present the methodology for modeling and simulation of an enterprise networking that is based on knowledge management and collaborative development of social technologies for SMEs in the major economic family settings in Bogota D.C. (from now FamiSMEs).The need for performance of the model is exposed, some background business networks and the proposed methodology through which seeks to achieve, which combines both knowledge management, as the simulation model so that it becomes a tool evaluation for companies and government entities that mesure possible impact on these organizations.