The chapter is divided into six sections, the first being this introduction. The second presents the professors and their socio-economic environment as well as the conceptual core of their teaching programs. The third reflects on the mechanisms of circulation of ideas from the center to periphery throughout the nineteenth century. The fourth explores the relation between the knowledge taught and the economic system of the Republic of New Granada. The fifth proposes an exercise of contrast between the ideas disseminated in the classroom and the economic environment of the United States of Colombia. The final section presents some concluding remarks.