The purpose of this chapter is to present the relationship between sustainability of micro and small enterprises (MSEs) in turbulent environments and technology. To achieve this objective, a questionnaire structured and validated in 2020 by the Latin American Studies Network in Management and Business (RELAYN, its abbreviation in Spanish) was applied to 401 directors of MSEs located in the neighborhoods of Candelaria, Bosa, Puente Aranda, and Tunjuelito in Bogota. For the development of this research, a correlational analysis is made, evaluating the degree of association between the variables of perception of knowledge and use of technologies and the increase in sales, increase in profit, and reduction of risk of closure of the establishment. The results show an association between the components of technology with the increase in sales, increase in profit, and reduction of risk of closure of the establishment.