Between 2017 and 2021, the RISE model (route of innovation and sustainability for enterprises) has been applied in 106 organizations of different sizes and economic sectors in the Colombian environment. From the results of application of the RISE, the following research question arises for the authors of this chapter: Which variables or descriptors better explain the financial performance of the EBITDA Margin and in which should a manager should concentrate his efforts for organizational sustainability, in terms of this indicator? The objective of this work is to present the analysis of the variables that best explain the financial performance of the EBITDA Marginl to facilitate the organizational sustainability of Colombian companies. The data were processed with the statistical package Statgraphic Centurion XVI, using factorial analysis with multiple regression, and seven variables were obtained from the 36 that make up the model, which explain at 51.15% the performance of the EBITDA.