Sustained low efficiency dialysis (SLED) is a hybrid technique of renal replacement therapy. It can be used through a mobile system of dialysis by a single-pass batch (Genius) or multifunctional dialysis system, with reduced flow and prolongation of treatment time. It has been used in critical patients who develop acute kidney injury. A patient with septic shock and acute kidney injury was treated with sustained low efficiency dialysis and column-dialyzier/cytosorb membranes.