Abstract Malaria is an endemic parasitosis in more than 80 countries and with a record of reported cases by 2020 of more than 200 million. Recent literature has been emphatic in increasingly demonstrating the economic impact and severity of disease caused by Plasmodium vivax. This case report decribes a A 19-year-old colombian male patient, active soldier, previously healthy, resident for 6 months in the city of Bogotá, reporting a clinical picture of 4 days of evolution characterized by quantified febrile spikes of up to 39 degrees, headache, arthralgia and several diarrheal episodes with non-dysenteric water content. Associated with the above, the patient presented a seizure of 3 minutes of duration with generalized tonic-clonic movements, superelevation of the gaze without relaxation of the sphincters, drowsiness and total amnesia of the event. He refers as the only relevant pathological history the presence of Malaria treated 6 months before while residing in the Amazon Department. In consideration of the referred history of malaria, it is decided to take a thick blood smear to search for haemoparasites whose result was positive for Plasmodium vivax. With the above findings, management began with intravenous artesunate under the consideration of complicated malaria by P. vivax with cerebral involment secondary to a relapse.