Approximately 80% of episodes of hiccups or singultus involve unilateral contraction of the right hemidiaphragm and typically follow an inspiratory peak.The pathophysiologic mechanism is not entirely clear.The hiccup centers are thought to be located in the hypothalamus, reticular formation, brain stem, dorsomedial nucleus, and cervical spinal cord between C3 and C5.The vast majority of hiccup episodes are benign and self-limited, ceasing within minutes; but persistent or intractable hiccups can also be found, which are usually associated with malignancy such as cancer and require timely medical management given the discomfort it produces and the negative impact on the patients quality of life.There are no specific guidelines for the management of intractable hiccups in cancer patients; however, pharmacological, non-pharmacological and interventional therapies have been reported to be effective.