To highlight an interesting case of Acute Macular Neuroretinopathy (AMN) in the context of dengue disease.A 70 year old woman from Ibagué, Colombia developed AMN during her hospitalization for dengue illness with warning signs. Her initial ophthalmic evaluation revealed a deep visual loss with no noticeable biomicroscopic findings and altered outer retinal layers in her macular optical coherence tomography (OCT). After a five year follow up, she maintains a poor visual acuity.There are few reported cases of AMN associated to dengue. This case report highlights the common physiopathological pathways between dengue and AMN, and the crossroads between vascular, infectious, and immune disorders.