The compressibility characteristics, effects of low-strain rate, and natural variability in fines content of Central Florida sands are examined in this paper. Soil samples arising from the same sedimentary depositional environment in the Central Florida region were extracted from a site near the University of Central Florida campus. Soil characterization methods included the results of index, X-ray diffraction, and scanning electron microscopy tests. Compressibility characteristics of the soils were studied under constant rate of strain conditions at different densities and low-strain rates on reconstituted sand specimens. The results were evaluated in terms of axial stress–strain response, overall compressibility properties, potential of compressibility, and fines content. This paper shows how a small variation in both vertical and horizontal distance at which the samples were extracted triggered significant differences in the compressibility characteristics of these soils. Negligible low-strain rate effects were observed in the tested specimens.