Refractory pruritus can be a symptom difficult to manage.We describe a case of a 37-year-old female patient with an oncological diagnosis of high-grade mesenchymal osteosarcoma in the left sacrum, hospitalized for urinary tract infection and polymicrobial bacteremia.During hospitalization, she presented pruritus of unknown cause, refractory to multiple treatments.Given the severity of symptoms and refractoriness, we administered aprepitant obtaining a complete resolution of the pruritus.With these findings, we raise the possibility of using aprepitant as a treatment for refractory pruritus.