The global health emergency generated by Covid-19 has transformed the traditional learning model, generating a sudden generalized foray into virtual learning environments. Process in which ease of use, perceived usefulness, and attitude toward technology play a fundamental role in accepting virtual platforms as a tool for the teaching-learning process. The objective was to evaluate the acceptance of the use of virtual platforms by university students in the times of the Coronavirus Pandemic (COVID-19). A confirmatory factor analysis was performed to evaluate the four constructs of the TAM technological acceptance model (perceived usefulness, ease of use, attitude, and intention to use) in a sample of 200 undergraduate students. It was concluded that the perceived utility and ease of use are antecedents of the attitude. This time, it is decisive of the intention to use virtual platforms in the academic activities of university students. Similarly, it was found that gender does not affect the acceptance of technology in the use of virtual platforms.