Rare and orphan diseases are a group of multiorgan disabilities that limit the life quality in young and adult patients, affecting the socio-economic burden for the families and the community.Despite the continuous attempts in research, no standardized and effective therapies are nowadays available.Orthosis supports and rehabilitation remain the unique possibilities to alleviate these challenging conditions.Among the emerging therapeutic odds, Pulsed Electromagnetic Fields (PEMFs) express anti-inflammatory and regenerative effects on musculoskeletal and parenchymal tissues.They have also shown intriguing properties to stimulate the central and peripheral nervous system either as Transcranial Magnetic Stimulation (TMS) and Low Frequency -High-Intensity -Pulsed electromagnetic Field (LF-HI-PEMFs) or Diamagnetic Therapy (Diamagneto-therapy).This last modulates brain plasticity and is effective in pain, reducing muscles contractures and tissue oedema.Our experience refers to the use of Diamagnetic Therapy to rare and orphan diseases and reports promising functional and behavioural results, opening the possibility of therapeutic applications integrated with conventional rehabilitative methods.