The effect of the meteorological variables in conjunction with the sedimentation and accumulation of particulate material on the light-gathering surface of solar panels is a problem that affects the efficiency of the energy conversion process in these devices. This paper analyzes the relationship between variables such as ambient temperature, relative humidity, and solar irradiance, in addition to the concentration of the particulate matter (PM) in the panels, with electrical parameters such as short circuit current (ISC), allowing to determine their effect on the energy efficiency of the solar-to-electric energy conversion process.To achieve the results presented, a 100W solar panel and 90 glass plates (7cm by 9cm) ordered on a surface next to the panels were used, emulating to be the surface of the panel, accumulating (both) particles during the whole study. For a period of 90 days, one plate was removed per day to determine the amount of accumulated particulate matter (MMP). The data of the meteorological variables were obtained daily by means of a portable weather station Ventage PRO 2, while the electrical parameters were taken with multimeters.The energy efficiency of solar panels depends on the condition of their light-gathering surface, this study reveals that the effect of the accumulation of particulate matter from the solar panel may begin to be significant at MMP greater than 0.0020 g. when losses grow linearly, from 10% in the generated current and scaling over periods of approximately 90 days; to about 30% difference between the generation of ISC values of the same solar radiation order.The meteorological variables can enhance the presence of the particulate material, with higher temperature and lower relative humidity, and greater sedimentation of particulate material was evident, these two variables being the most influential.