Machine learning tools have been employed for problem solutions in bioinformatics. However, the parameters tuning of these models cam imply additional difficulties around the specific technique used to classify. In this work data from protein sequences was applied to three auto machine learning strategies to determine the type of mutation for the Neurofibromatosis disease. Results show that the parameters in the machine learning models were found automatically. In addition, these tools were relevant to determine relations between the amino-acids in the protein sequence.