Acute human Parvovirus B19 infection is a well-known cause of infectious erythema in pediatric age.However, in adult patient clinical picture is different but characteristic presenting with erythema, acute polyarthritis, systemic inflammation, hepatic enzymes elevation and anemia.Here, we present a case report about a nonpregnant immunocompetent adult female with a compelling symptom and a serological confirmation also a suspected close epidemiological contact was an infant with infectious erythema.We describe the clinical spectrum of this infection.To recognize its clinical picture and laboratory abnormalities, as well as the infant as a close contact, should make the clinician consider acute human parvovirus B19 infection as main differential diagnosis.