The design of distributed energy systems requires to implement methodologies within the framework of sustainable development. Accordingly, this work deals with the conceptual design of an isolated energy system by analyzing the economic, environmental, and social dimensions of sustainability. The case study corresponds to a remote location in the Colombian Amazon. The design of the energy system was performed through an optimization-based approach. The optimization problem consists in the multicriteria minimization of the total annualized cost, the CO <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</inf> emissions, the water consumption, and the inherent safety index. According to the obtained results, it was determined that at least a PV surface of 9800 m <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> must be installed to satisfy the electricity needs of the considered community (4160 inhabitants). In this case, the demand of methane should be entirely covered by biomethane from an anaerobic digestion process. Nevertheless, by installing a PV area of 24150 m <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> , electricity and methane demands could be supplied from PV-based electricity and by using the power-to-gas pathway. In such a case, around 854 ton CO <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</inf> /year are required for the methanation process, which must be captured from the atmosphere.