This paper explores the reasons that led many Catholics to support the candidacy of Donald Trump in the 2016 and 2020 presidential elections in the United States and the role played by the leadership of the U.S. Catholic bishops in the electoral process. Also explored are the outlines of an alternative approach, shaped by the more holistic “consistent ethic of life” contained in the teachings of Pope Francis. Attention is given to how this Francis-inspired alternative could provide a model for more constructive and prophetic engagement of the U.S. Catholic Church in the political arena. Brief profiles are presented of several U.S. Catholic bishops modeling this more holistic approach.