Abstract Background: Invasive monitoring of intracranial pressure is currently the only accepted method for the safe diagnosis and treatment of intracranial hypertension, but it is subject to hemorrhage, infection and malfunction. Ultrasound of the optic nerve sheath diameter is a non-invasive alternative that is cost effective and available at the bedside. The objective of this study was to correlate intracranial pressure and ultrasonography of the optic nerve sheath in an experimental animal model of cerebral hematoma. Materials and Methods : An experimental study was conducted on 30 male and female pigs wighing about 20 kg. The diameter of the optic nerve sheath was measured by ultrasound at different points of intracranial pressure. Intracranial pressure was simultaneously measured with an intraparenchymal catheter, and laboratory and hemodynamic data was collected from the animals. The values were correlated with each other to explore the application of this procedure in different clinical situations involving intracranial hypertension. Results: All the variables obtained by ONSD ultrasonography (Left Optic nerve LON, Rigth optic nerve RON and Avarage of Optic Nerve sheath AON) were statistically significant to predict the ICP value. AON presentation changes in relation to baseline from the moment of balloon inflation. AON proved to be the best parameter for predicting ICP and presented the best correlation. AON showed a delay of 30 minutes compared to ICP decrease, as it maintained values higher than baseline values at the ballon deflation moment (p = 0.016). Thus, intracranial pressure can be predicted using the linear function: -80.5 + 238.2 × the optic nerve sheath diameter. Conclusion: Optic nerve sheath diameter ultrasound is a reliable method for predicting intracranial pressure.