Background: COPD is highly underdiagnosed, thus applying clinical prediction scales such as the COPD Diagnostic Questionnaire (CDQ) helps to address this problem. Objective: To evaluate the criterion validity and in-tra-rater reproducibility of the questionnaire CDQ in a Colombian population.Materials and methods: A prospective cohort study. The reproducibility was assessed with the Kappa sta-tistic and the intraclass correlation coefficient (ICC). Validity was established with the score obtained from the CDQ questionnaire and the spirometry values (FEV1/ FVC <0.7 post B2). The area under the curve of the receiver operating characteristics (ACOR), sen-sitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) were calculated. A statistically significant p <0.05 was considered.Results: A total of 1,423 subjects were recruited. The ICC between the two moments of the questionnaire evaluation was 0.781 (95%CI: 0.744-0.813), and a ka-ppa of 0.65 (p <0.001) was found for the scoring sys-tems with low probability of COPD CDQ ≤ 16.5, inter-mediate probability of CDQ COPD > 16.5 and < 19.5, and high probability of CDQ COPD ≥ 19.6. The ACOR was 0.68 (95%CI: 0.647-0.712), a sensitivity of 79% and a specificity of 44% were obtained for a score ≥16.5, with a PPV of 26% and a NPV of 86%.Conclusions: The CDQ questionnaire has a regu-lar performance for the diagnosis of COPD with an ACOR similar to other questionnaires, it can be useful in underdiagnosed patients. The optimal cut-off point for this population was 16.5.