Introduction and Objective: Cardiac tumors are often unrecognized until autopsies are performed or diagnosed from routine studies based on unspecific symptoms.The most common type of tumor is the myxoma, although rare, upon diagnosis an urgent surgical resection is often required.Previously the ideal surgical approach was a standard median sternotomy, however recently newer surgical techniques have been employed with excellent results.We describe a recent surgical approach via the right lateral minithoracotomy as a minimally invasive intervention with three cases that evidence an appropriate and ideal surgical approach.Method and Patients: We present three cases of minimally invasive myxoma resection via the right lateral minithoracotomy.Results and discussion: In this three-case series study, no complications were reported peri-operatively nor at the 6 and 12-month follow-ups.In comparison with international literature, surgical approaches in Colombia are comparable with successful resection and little or no complications peri-operatively.Conclusions: The right lateral minithoracotomy appears to be a safe approach in myxoma resection.We hope to enhance and promote the surgical community in Colombia to opt for alternative less invasive approaches in these type of cases, to ensure excellent results and promote further research as seen in other countries.