With the spread of the COVID-19 virus, containment measures such as home confinement were implemented, generating stress, anxiety, depression and aggravation of pre-existing diseases in the population, including dentists, who have also been affected due to the risk involved in practicing their profession. Objective: To determine the impact of mandatory social isolation measures on the subjective well-being of Latin American and Caribbean dentists during the community quarantine due to the COVID-19 pandemic in 2020.A Cross-sectional study in a sample of 1195 dentists from 21 countries in Latin America and the Caribbean. The main outcome was Subjective Well-Being, evaluated through the World Health Organization Well-Being Index (WHO-5). In addition, sociodemographic characteristics, variables related to the community quarantine due to the COVID-19 pandemic and health variables were considered. A descriptive, bivariate and multivariate (multiple linear regression) analysis was performed to observe the behavior of the variables.A multiple linear regression analysis was performed, where all the variables included within dimensions, were distributed in a single model, observing an R2% of 9.000 (p<0.001), where the R2% change was significant (p<0.001) and a constant of 44.190; likewise, within this model, the variable follow-up of preventive measures against COVID-19 reported an unstandardized regression coefficient (b) of 2. 316 (95%CI:1.133-3.499;p<0.001), the self-perceived level of concern against COVID-19 obtained a (b) of -5.470 (95%CI:-7.509--3.430; p<0.001), the biological sex variable manifested a (b) of -5.417 (95%CI: - 1.157-1.910; p<0.001); finally, the level of economic income during compulsory social isolation presented a (b)=5.354 (CI95%:3.461- 7.247; p<0.001).An association was found between subjective well-being and variables related to the social impact of the COVID-19 pandemic, such as following preventive measures, concern about the pandemic and economic factors (decrease in income level), in addition to biologic sex. Follow-up strategies are required for these dental professionals, considering that social isolation measures have continued in many of the countries. Key words:Quarantine, Coronavirus infections, WHO-5, Cross-sectional studies, Latin America, Caribbean Region.