This study evaluated the effect of compaction on the physical-mechanical performance of hot asphalt mixture type MDC-19 (According to the National Institute of Highways of Colombia INVIAS). In the first instance, the mixture design was carried out by means of the Marshall methodology in order to determine the asphalt content. The asphalt mixture was then manufactured and compacted at temperatures of 160, 140, 120, 100 and 80 °C, respectively. Subsequently, for each compaction temperature, the volumetric composition and the resistance parameters to the action of the monotonic load were evaluated by means of the Marshall test. As a result, the reduction of the compaction temperature causes a significant increase in the volume of air. This causes a decrease in Marshall stiffness, between 10% and 70% for the temperature range analyzed.