Appendicular agenesis is a rare condition that accounts for 1 of every 100,000 exploratory laparotomies, usually in clinical suspicion of appendiceal inflammatory processes with higher incidence in adults.We present a case of a 19-year-old female with appendicular agenesis who underwent exploratory laparoscopy in the context of appendiceal inflammatory process.Vermiform appendix agenesis is a challenging diagnosis made in most cases as an intraoperatively finding. Systematic revision of abdominal cavity should be performed after ruling out other causes of acute abdomen. No implications have been described in patients with appendix abnormalities.