This work estimates the impact of the preventive isolation measures adopted by national and regional authorities in Colombia to answer the following question: Where do the government's isolation measures effectively reduce the number of COVID 19 infections and deaths? Using official information reported by the Ministry of Health and constructing a panel data structure, a model of differences in differences suggested by Cerulli and Ventura is estimated. Estimates of the impact of containment measures show that the peak is delayed and the number of infections and deaths reduced. The government's response to the pandemic on diseases has a significant dynamic impact over time once implemented. The pre-treatment period was significantly affected by the current treatment.