Aim: This systematic review and meta-analysis were aimed to determine the efficacy of Nintendo Wii (NW) in patients who have undergone knee surgery.
 Methods: In literature search of this systematic review and meta-analysis, Cochrane Database of Systematic Review, MEDLINE (EBSCO), Physiotherapy Evidence Database (PEDro), CINAHL (EBSCO), PUBMED, OVID, Science Direct, Scopus, Academic Search Complete, and Google Scholar databases were used. The database search was limited to the period from 2006 until August 2021 so as to capture more recent publications. 
 Results: The search strategy was applied with the limitation of date and language and this initial electronic search resulted in 203 relevant studies. Of these, 41 full-text articles met the initial criteria and were retrieved for review, with 4 studies meeting the final inclusion criteria. The mean methodological quality of all the studies was determined as 4.25 out of 10 on the PEDro scale. The meta-analysis indicated that NW training in addition to conventional therapy was statistically more effective than only conventional physiotherapy in reducing pain (SMD=-0.746; 95% CI=-1.333, -0.160; p = 0.013) and functionality (SMD=-0.744; 95% CI=0.260, 1.228; p = 0.003). 
 Discussion: NW training can be a promising tool on the pain, functionality, balance, co-ordination and proprioception of patients who have undergone knee surgery. There is a need for further studies of high quality to examine the efficacy of NW in rehabilitation.