Sir, We read with great interest the article published by Thankappan et al.[1] entitled "The coronavirus disease-2019 pandemic and noncommunicable diseases-need for primary health care system strengthening," where the author highlights the need to strengthen primary health systems, considering that patients with chronic noncommunicable diseases are at higher risk of developing the severe phenotype of COVID-19 and die.[1] Furthermore, the political and security modifications that caused the confinement and restrictions impacted negatively both directly and indirectly on chronic noncommunicable diseases, probably adversely modifying their prognosis.[1] We thank the authors for their comments. However, we would like to discuss an idea closely related to the topic, but which is associated with post-COVID 19 syndrome, and consists of the need to create specialized centers and rehabilitation in primary care for patients with post-COVID 19 syndrome, and patients with chronic decompensated diseases. Post-COVID 19 syndrome consists of the persistence of signs and/or symptoms following the acute phase of COVID-19, in patients who have developed any phenotype of this disease and that compromises the functional capacity of the affected person.[23] Depending on the target organ injury during the acute phase of COVID-19, which may or may not be symptomatic,[4] phenotypes of post-COVID 19 syndrome have been described, such as post-COVID 19 neurological syndrome,[5] which may occur in patients who did not even present neurological manifestations during the acute phase, nor have any previous neurological disorder.[5] One of the most important questions at present and about this syndrome is the prognosis and mortality risk in patients with chronic noncommunicable diseases such as diabetes mellitus type II, hypertension, chronic kidney disease, heart failure, coronary artery disease, dementia, or neurovascular disease, where the systemic inflammatory process can cause decompensation of the chronic condition and adversely modify the functional prognosis or final outcome of the patient. Alves et al.[6] conducted a systematic review and meta-analysis, where they found that patients with dementia, diabetes, hypertension, and chronic kidney disease, during their hospital stay or during the post-COVID phase, have a cumulative case fatality of 27.68 (95% confidence interval; 15.66–41.57).[6] Another very interesting study, which even demonstrated target organ injury without immediate manifestation, was that of Drakos et al.,[4] who evaluated coronary microvascular disease in COVID-19 patients by cardiovascular magnetic resonance imaging, showing that patients who had COVID-19 had significantly reduced global myocardial perfusion reserve (2.73 [2.10–4.15-11] vs. 4.82 [3.70–6. 68],P= 0.005), significantly increased coronary sinus flow at rest (1.78 ml/min [1.19–2.23 ml/min] vs. 1.14 ml/min [0.91–1.32 ml/min],P= 0.048), and reduced coronary sinus flow during stress activity (3.33 ml/min [2.76–4.20 ml/min] vs. 5.32 ml/min [3.66–5.52 ml/min],P= 0.05), compared to controls.[4] Based on the above, the authors concluded that there is cardiac microvascular injury in COVID-19 patients, which may trigger major cardiovascular events in the post-COVID-19 phase, and this is one of the reasons that would explain the persistence of fatigue and dyspnea during this phase.[4] Many of these silent pathophysiological mechanisms may be responsible for the autonomic dysfunction and symptoms of fatigue and dyspnea (most prevalent [>60% of patients]) in post-COVID 19 syndrome,[23] mainly due to involvement of the cardiovascular system, which may be intensified in patients with previous heart disease. In this order of ideas, one of the objectives that need to be raised and developed in the short- and long-term, is the rehabilitation process of these patients,[7] in order to recover and maintain functional capacity and perform strict monitoring to control morbidity and mortality rates.[7] To this end, we suggest the creation of specialized post-COVID 19 centers, which should be promoted especially in low- and middle-income countries, where there are greater difficulties in accessing quality health services. Financial support and sponsorship The research was totally funded by the researchers Conflicts of interest There are no conflicts of interest. Acknowledgments The research was totally funded by the researchers.