Introduction: Sepsis-associated myocardial dysfunction has been described in relation to left ventricular function and reported to have a variable correlation with mortality. However, the extent to which right ventricular (RV) dysfunction contributes to myocardial dysfunction and a poor prognosis in sepsis remains unknown. Our aim is to investigate the association between RV dysfunction and mortality in patients with sepsis. Methods: We performed a systematic review of the literature. We systematically searched Cochrane, Embase, MEDLINE, Scopus and Web of Science for full-text articles from inception to June 2020. Studies were included if they reported RV function and mortality in patients with sepsis using echocardiography. Data was extracted using a collection form designed a priori . Significance was determined by a two-tailed p value < 0.05. The present study was registered in the PROSPERO (CRD42020204423). Hypothesis: RV dysfunction is associated to mortality in adult patients with sepsis. Results: Six studies including 526 patients were selected for final analysis. Patients had a mean age of 57 years, 45% were females, and there was an overall mortality of 37%. In three studies, transthoracic echocardiography was performed within 24h of sepsis diagnosis, and reported Tricuspid annular plane systolic excursion (TAPSE) in a total of 366 patients. In pooled analysis, survivors had a higher TAPSE compared to non-survivors ((SMD):1.89 (95%CI 0.14-3.655) p=0.03, Figure1). All other parameters of RV dysfunction assessed did not have a statistically significant difference between survivors and non-survivors (Figure 2-6). Conclusion: RV dysfunction as demonstrated by a lower TAPSE is associated with higher mortality in patients with sepsis and/or septic shock. This data suggest that RV dysfunction is an important contributor to sepsis-associated myocardial dysfunction and worsening prognosis in patients with sepsis.