Ti prosthesis have shown better biological compatibility, mechanical performance, and resistance to corrosion in cases of bone replacements. Nevertheless, fully dense Ti in connection with bone-host tissues show stress-shielding phenomenon that, together with the development of frequent undesirable microbial infections, may lead to implant failures. To overcome these issues, the present study aimed at the development of a novel combination of a chemically functionalized porous Ti substrate with a potentially therapeutic AgNPs coating. Fully dense and porous Ti substrates (30 and 60 vol.%, 100–200 and 355–500 μm, as spacer particles) were studied. Ti surface was treated with acid or basic medium followed by silanization and deposition of AgNPs by “submerged” and “in situ” methods. In general, for similar porosity, mechanical resistance decreased as pore size increased. Acidic reagent and submerged methodology were the best combination for fully dense Ti substrates. Hence, they were also employed for porous Ti substrates. Depending on the porosity of the substrates, variations can be observed both in the size and degree of agglomeration of the deposited AgNPs, entailing differences in the antibacterial behavior of the samples.