The symptom of fatigue is considered incapacitating and affects the quality of life of people with chronic kidney disease, undergoing hemodialysis treatment. Objective: to assess the prevalence, intensity, and severity of the symptoms of fatigue in people with chronic kidney disease in hemodialysis treatment. Descriptive quantitative study, in which 335 in hemodialysis treatment participated. For the data collection, were used the 100mm Visual Analog Scale", the scale of severity of the fatigue, and a sociodemographic questionnaire. Were analyzed variable dependent on the fatigue scale, with the independent variables of sociodemographic and clinical characterization. 58% were identified as male, aged between 20-59 years old in 52.2%, predominance of White color in 68.2%, 68.6% with low schooling, retirement as main income in 55.7%, yields between R$ 800.01 and R$ 1760.00 in 42.4%, with a prevalence of fatigue were 63.0%, severe fatigue in viúvos (35.2%) and women (27.6%), being that the main comorbidities of Systemic Arterial Hypertension (40.9%). At the intensity of fatigue, it has a mean value of 42.3 (DP = 32.2) and at the severity of fatigue, it has a mean value of 35.8 (DP = 17.8). We evidenced that the socioeconomic factor in comorbidities influences the symptoms of fatigue in women, widowers, and the elderly. The use of assessment instruments can contribute to help us address the sickness, and consequent- ly, or improve the quality of life of these people.