Trabecular juvenile ossifying fibroma is a rare fibro-osseous lesion affecting the craniofacial skeleton occurring commonly in children and young adults. Tumor clinical behavior is highly aggressive with invasion of adjacent anatomic structures. Because of its high recurrence rate complete excision is necessary, but this one could be facial mutilating. This case report presents a 23-year-old female patient with a trabecular juvenile ossifying fibroma of the right maxilla, expanding into the orbit and zygomatic bone. The report also shows the multidisciplinary surgical management of this lesion with successful preservation of optic nerve function and facial aesthetics.