Studying sub-atmospheric pressure patterns in emptying pipeline systems is crucial because these processes could cause collapses depending on the installation conditions (the underground pipe covering height, type, fill, and pipeline stiffness class). Pipeline studies have focused more on filling than on emptying processes. This study presents an analysis of the following variables: air pocket pressure, water velocity, and water column length during the emptying of an irregular pipeline without an air valve by two-dimensional computational fluid dynamics (2D CFD) model simulation using the software OpenFOAM. The mathematical model predicts the experimental values of the study variables. Water velocity vectors are also analysed within the experimental facility, assessing the sensitivity of the drain valve to different openings and changes in water column length during the hydraulic phenomenon.