Aim: The objective was to determine the prevalence of the potentially inappropriate antipsychotics and anticholinergics used in patients with Parkinson's disease. Materials & methods: A cross-sectional study identified the prescription of antipsychotics, anticholinergics and drugs for the treatment of Parkinson's disease. The anticholinergic burden was evaluated, and quetiapine and clozapine were considered to be adequate antipsychotics. Results: 2965 patients with Parkinson's disease were identified. The presence of psychiatric disorders and other neurological pathologies was associated with a greater probability of receiving potentially inappropriate antipsychotic prescriptions. The presence of greater number of comorbidities was associated with a greater probability of receiving anticholinergics. Conclusion: Older age and associated comorbidities, especially psychiatric and neurological comorbidities, increase the likelihood of patients with Parkinson's disease being prescribed antipsychotics and anticholinergics.Lay abstract People with Parkinson's disease have movement disorders, and some of them will frequently have medical problems such as constipation, urinary incontinence, cognitive impairment, depression and anxiety, among others. Many medications can make these symptoms worse, so they can be considered potentially inappropriate prescriptions. From a drug dispensing database, we found 2965 patients with a diagnosis of Parkinson's disease, in which more than a third of them presented this type of potentially inappropriate prescriptions, especially those patients of older age and those who had other neurological or psychiatric diseases.