This study aimed to compare the effects of two different cargo management systems (one powered system, i.e., the RazerLift®, and one Traditional system) on the biomechanical and perceived exertion experienced by workers when performing routine ladder loading and unloading tasks. Seven experienced workers performed ladder loading and unloading tasks. Compared to when the Traditional system was being used, the cumulative static low-back compression force was reduced by 57.9% (p < 0.05) and 39.3% (p < 0.05) when the RazerLift® was being used to perform ladder loading and unloading tasks, respectively. Overall, the cumulative shoulder flexor moments were reduced by 34.8% (p < 0.05) and 41.3% (p < 0.05) when the RazerLift® was being used to perform ladder loading and unloading tasks, respectively. Overall, the perceived exertion score was reduced by 250.1% (p < 0.05) when the RazerLift® was being used compared to the Traditional system. In conclusion, our study demonstrated that the RazerLift® reduces the biomechanical and psychophysical exposure associated with the development of musculoskeletal disorders while performing ladder loading and unloading tasks.